Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …

Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood
vessel wall and represent the conduit for fluid transport in and out of the brain. PVS are …

Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% of
dementias. We aimed to investigate the role of cerebral blood flow (CBF) and intracranial …

Cerebrovascular reactivity (CVR), is important for determining future risk of cerebrovascular
disease. It is unclear if primary aging is associated with reductions in CVR because previous …

Background Characterizing cerebrovascular hemodynamics in older adults is important for
identifying disease and understanding normal neurovascular aging. Four-dimensional (4D) …

Enlarged perivascular spaces (ePVS) are difficult to quantify, and their etiologies and
consequences are poorly understood. Vanderbilt Memory and Aging Project participants (n …

Clinical evidence shows vascular factors may co-occur and complicate the expression of
Alzheimer's disease (AD); yet, the pathologic mechanisms and involvement of different …

Alterations in cerebral blood flow are common in several neurological diseases among the
elderly including stroke, cerebral small vessel disease, vascular dementia, and Alzheimer's …

The brain's vasculature is essential for brain health and its dysfunction contributes to the
onset and development of many dementias and neurological disorders. While numerous in …

The central arteries dampen the pulsatile forces from myocardial contraction, limiting the
pulsatility that reaches the cerebral vasculature, although there are limited data on this …