Transposons are mobile genetic elements evolved to execute highly efficient integration of
their genes into the genomes of their host cells. These natural DNA transfer vehicles have …

The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

Due to the tolerance of mismatches between gRNA and targeting sequence, base editors
frequently induce unwanted Cas9-dependent off-target mutations. Here, to develop models …

Abnormal gene expression level or expression of genes containing deleterious mutations
are two of the main determinants which lead to genetic disease. To obtain a therapeutic …

Recently, increased interest in the use of Tregs as adoptive cell therapy for the treatment of
autoimmune diseases and transplant rejection had led to several advances in the field …

Molecular medicine has entered a high-tech age that provides curative treatments of
complex genetic diseases through genetically engineered cellular medicinal products. Their …

Abstract The Sleeping Beauty transposon system is a nonviral DNA transfer tool capable of
efficiently mediating transposition‐based, stable integration of DNA sequences of choice …

An ideal tool for gene therapy would enable efficient gene integration at predetermined sites
in the human genome. Here we demonstrate biased genome-wide integration of the …

Immune checkpoint-inhibitor combinations are the best therapeutic option for advanced
hepatocellular carcinoma (HCC) patients, but improvements in efficacy are needed to …

Chimeric Antigen Receptor (CAR) T-cell therapy has become a new therapeutic reality for
refractory and relapsed leukemia patients and is also emerging as a potential therapeutic …