The risk factors for hypertension are only partly known, and accounts for the some of the
deficiencies in current primary prevention strategies and in the design of new drugs for the …

Cytokines are produced in a variety of tissues and regulate the expression of a number of
inflammatory molecules, leading to destabilization and finally rupture of vulnerable …

Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a
strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to …

Endothelium-derived nitric oxide (NO) is an important regulator of vascular function. NO is
produced by endothelial NO synthase (eNOS), whose expression is downregulated by …

Atherosclerosis is a widespread disease of the arterial system that is generated by injury to
the vasculature due to hypercholesterolemia, hypertension and inflammatory diseases. In …

Extracellular vesicles (EVs) are nanosized vesicles released from most cell types that play a
key role in cell-to-cell communication by carrying DNA, non-coding RNAs, proteins and …

The expression of inducible nitric-oxide synthase (iNOS) and subsequent" high-output" nitric
oxide (NO) production underlies the systemic hypotension, inadequate tissue perfusion, and …

Objectives: Ankylosing spondylitis (AS) is associated with increased cardiovascular
morbidity and mortality. Microvascular function has been linked to several risk factors for …

It is well documented that in patients with coarctation of the aorta life expectancy is not
normal even after successful coarctation repair (SCR), primarily due to cardiovascular …

There is good epidemiological evidence that patients with autoimmune rheumatic disease
states, particularly rheumatoid arthritis, have an increased risk of cardiovascular morbidity …