The many functions of ESCRTs

M Vietri, M Radulovic, H Stenmark - Nature reviews Molecular cell …, 2020 - nature.com
Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

Cellular functions and molecular mechanisms of the ESCRT membrane-scission machinery

L Christ, C Raiborg, EM Wenzel, C Campsteijn… - Trends in biochemical …, 2017 - cell.com
The endosomal sorting complex required for transport (ESCRT) machinery is an assembly of
protein subcomplexes (ESCRT I-III) that cooperate with the ATPase VPS4 to mediate …

Exosomes and other extracellular vesicles in host–pathogen interactions

JS Schorey, Y Cheng, PP Singh, VL Smith - EMBO reports, 2015 - embopress.org
An effective immune response requires the engagement of host receptors by pathogen‐
derived molecules and the stimulation of an appropriate cellular response. Therefore, a …

Reverse-topology membrane scission by the ESCRT proteins

J Schöneberg, IH Lee, JH Iwasa… - Nature reviews Molecular …, 2017 - nature.com
The narrow membrane necks formed during viral, exosomal and intra-endosomal budding
from membranes, as well as during cytokinesis and related processes, have interiors that …

Single-virus tracking: from imaging methodologies to virological applications

SL Liu, ZG Wang, HY Xie, AA Liu, DC Lamb… - Chemical …, 2020 - ACS Publications
Uncovering the mechanisms of virus infection and assembly is crucial for preventing the
spread of viruses and treating viral disease. The technique of single-virus tracking (SVT) …

HIV-1 assembly, budding, and maturation

WI Sundquist, HG Kräusslich - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

Virus budding and the ESCRT pathway

J Votteler, WI Sundquist - Cell host & microbe, 2013 - cell.com
Enveloped viruses escape infected cells by budding through limiting membranes. In the
decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes …

Molecular mechanisms of the membrane sculpting ESCRT pathway

WM Henne, H Stenmark… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body
(MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell …

Multivesicular body morphogenesis

PI Hanson, A Cashikar - Annual review of cell and …, 2012 - annualreviews.org
Multivesicular bodies (MVBs) are unique organelles in the endocytic pathway that contain
vesicles in their lumen. Sorting and incorporation of material into such vesicles is a critical …

Structures, functions, and dynamics of ESCRT-III/Vps4 membrane remodeling and fission complexes

J McCullough, A Frost… - Annual review of cell and …, 2018 - annualreviews.org
The endosomal sorting complexes required for transport (ESCRT) pathway mediates
cellular membrane remodeling and fission reactions. The pathway comprises five core …