The concept of gene therapy originated in the mid twentieth century and was perceived as a
revolutionary technology with the promise to cure almost any disease of which the molecular …

Recent advances strongly suggest that mRNA rather than DNA will be the nucleotide basis
for a new class of vaccines and drugs. Therapeutic cancer vaccines against a variety of …

Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to
desirable complete remissions of murine colon tumors treated with single radiation dose of …

Triple‐negative breast cancer (TNBC) represents the most aggressive breast tumor subtype.
However, the molecular determinants responsible for the metastatic TNBC phenotype are …

In subunit vaccines, strong CD8+ T-cell responses are desired, yet they are elusive at
reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via …

The sentinel or tumor-draining lymph node (tdLN) serves as a metastatic niche for many
solid tumors and is altered via tumor-derived factors that support tumor progression and …

Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is
responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia …

We hypothesized that the co-entrapment of melanoma-associated antigens and the Toll-like
receptor (TLR) ligands Poly (I: C) and CpG, known to be Th1-immunopotentiators, in …

The conditions leading to the activation/differentiation of T-helper (Th) cells dedicated for B-
cell antibody production are still poorly characterized. We now demonstrate that interleukin …

An optimal anticancer vaccine probably requires the cooperation of both CD4+ Th cells and
CD8+ CTLs. A promising tool in cancer immunotherapy is, therefore, the genetic …