Targeting apoptosis pathways in cancer and perspectives with natural compounds from mother nature

FM Millimouno, J Dong, L Yang, J Li, X Li - Cancer prevention research, 2014 - AACR
Although the incidences are increasing day after day, scientists and researchers taken
individually or by research group are trying to fight against cancer by several ways and also …

Deconvoluting the role of reactive oxygen species and autophagy in human diseases

X Wen, J Wu, F Wang, B Liu, C Huang, Y Wei - Free Radical Biology and …, 2013 - Elsevier
Reactive oxygen species (ROS), chemically reactive molecules containing oxygen, can form
as a natural byproduct of the normal metabolism of oxygen and also have their crucial roles …

[HTML][HTML] Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer

F Zhou, H Gao, L Shang, J Li, M Zhang, S Wang… - Journal of Experimental …, 2023 - Springer
Background The incidence of colorectal cancer and cancer death rate are increasing every
year, and the affected population is becoming younger. Traditional Chinese medicine …

Discovery and development of natural product oridonin-inspired anticancer agents

Y Ding, C Ding, N Ye, Z Liu, EA Wold, H Chen… - European journal of …, 2016 - Elsevier
Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

[HTML][HTML] Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

M Cai, L Qin, L You, Y Yao, H Wu, Z Zhang, L Zhang… - RSC …, 2020 - pubs.rsc.org
Metal organic frameworks (MOFs) are widely used in drug carrier research due to their
tunability. The properties of MOFs can be adjusted through incorporation of mono …

[HTML][HTML] Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound

D Li, T Han, J Liao, X Hu, S Xu, K Tian, X Gu… - International Journal of …, 2016 - mdpi.com
Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon
species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological …

ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells

D Zhang, Q Zhou, D Huang, L He, H Zhang… - Biochemical and …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the most common malignant neoplasms with high
mortality worldwide. Oridonin, a diterpenoid isolated from the Chinese medicinal herb …

[HTML][HTML] Identifying molecular targets of lifestyle modifications in colon cancer prevention

MM Derry, K Raina, C Agarwal, R Agarwal - Frontiers in oncology, 2013 - frontiersin.org
One in four deaths in the United States is cancer-related, and colorectal cancer (CRC) is the
second leading cause of cancer-associated deaths. Screening strategies are utilized but …

[HTML][HTML] Validation of suitable reference genes by various algorithms for gene expression analysis in Isodon rubescens under different abiotic stresses

C Lian, B Zhang, J Yang, JX Lan, H Yang, K Guo… - Scientific Reports, 2022 - nature.com
Abstract Isodon rubescens (Hemsley) H. Hara (Lamiaceae) is a traditional Chinese
medicine plant that has been used to treat various human diseases. Oridonin is one of the …

[HTML][HTML] Targeting signaling pathways in epithelial ovarian cancer

E Smolle, V Taucher, M Pichler, E Petru, S Lax… - International journal of …, 2013 - mdpi.com
Ovarian carcinoma (OC) is the most lethal gynecological malignancy. Response to platinum-
based chemotherapy is poor in some patients and, thus, current research is focusing on new …