Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet
transplantation has been shown to be a promising therapy for patients with Type I Diabetes …

Pancreatic islet transplantation can cure diabetes but requires accessible, high-quality islets
in sufficient quantities. Cryopreservation could solve islet supply chain challenges by …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones
insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and …

Dysfunction of pancreatic δ cells contributes to the etiology of diabetes. Despite their
important role, human δ cells are scarce, limiting physiological studies and drug discovery …

Understanding the root causes of autoimmune diseases is hampered by the inability to
access relevant human tissues and identify the time of disease onset. To examine the …

Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …

Tremendous progress has been made over the last two decades in the field of pancreatic
beta cell replacement therapy as a curative measure for diabetes. Transplantation studies …

Recapitulation of embryonic pancreatic development has enabled development of methods
for in vitro islet cell differentiation using human pluripotent stem cells (hPSCs), which have …