Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Calcium (Ca2+) dysregulation is a hallmark of heart failure and is characterized by impaired
Ca2+ sequestration into the sarcoplasmic reticulum (SR) by the SR-Ca2+-ATPase (SERCA) …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …

Background—Ca2+-dependent signaling through CaM Kinase II (CaMKII) and calcineurin
was suggested to contribute to adverse cardiac remodeling. However, the relative …

The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

Cardiomyocyte proteostasis is mediated by the ubiquitin/proteasome system (UPS) and
autophagy/lysosome system and is fundamental for cardiac adaptation to both physiologic …

Abstract Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle
physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (CSRP3) …

MLP (muscle LIM protein)-deficient mice count among the first mouse models for dilated
cardiomyopathy (DCM), yet the exact role of MLP in cardiac signalling processes is still …