The technical development of high‐throughput sequencing technologies and the parallel
development of targeted therapies in the last decade have enabled a transition from …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Pancreatic ductal adenocarcinoma (PDAC) is a highly heterogeneous tumor comprising
pancreatic cancer cells, fibroblasts, immune cells, vascular epithelial cells, and other cells in …

The tumor microenvironment, particularly the immune microenvironment, plays an
indispensable role in the malignant progression and metastasis of gastric cancer (GC). As …

Hyaluronic acid (HA) is a major component of the extracellular matrix, providing essential
mechanical scaffolding for cells and, at the same time, mediating essential biochemical …

Pancreatic cancer is a major cause of cancer-related death, but despondently, the outlook
and prognosis for this resistant type of tumor have remained grim for a long time. Currently, it …

Pancreatic cancer (PC) remains a leading cause of mortality worldwide due to the absence
of early detection methods and the low success rates of traditional therapeutic strategies …

Despite the efforts, pancreatic ductal adenocarcinoma (PDAC) is still highly lethal.
Therapeutic challenges reside in late diagnosis and establishment of peculiar tumor …

Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is characterized by a highly
desmoplastic and extreme immunosuppressive tumor microenvironment (TME), which …

Hyaluronan (HA) has gained significant attention in cancer research for its role in
modulating chemoresistance. This review aims to elucidate the mechanisms by which HA …