Ibuprofen: pharmacology, efficacy and safety
KD Rainsford - Inflammopharmacology, 2009 - Springer
Objectives This review attempts to bring together information from a large number of recent
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …
studies on the clinical uses, safety and pharmacological properties of ibuprofen. Ibuprofen is …
Terpenoids: natural products for cancer therapy
Introduction: Terpenoids constitute the largest class of natural products and are a rich
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …
reservoir of candidate compounds for drug discovery. Recent efforts into the research and …
Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
R Kannaiyan, MK Shanmugam, G Sethi - Cancer letters, 2011 - Elsevier
Identification of active constituents and their molecular targets from traditional medicine is an
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …
enormous opportunity for modern pharmacology. Celastrol is one such compound that was …
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB–regulated gene products and TAK1 …
Celastrol, a quinone methide triterpene derived from the medicinal plant Tripterygium
wilfordii, has been used to treat chronic inflammatory and autoimmune diseases, but its …
wilfordii, has been used to treat chronic inflammatory and autoimmune diseases, but its …
Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
X Pang, Z Yi, J Zhang, B Lu, B Sung, W Qu… - Cancer research, 2010 - AACR
Understanding the molecular basis and target of traditional medicine is critical for drug
development. Celastrol, derived from Trypterygium wilfordii Hook F.(“Thunder of God Vine”) …
development. Celastrol, derived from Trypterygium wilfordii Hook F.(“Thunder of God Vine”) …
Control of autoimmune inflammation by celastrol, a natural triterpenoid
SH Venkatesha, S Dudics, B Astry… - Fems Pathogens and …, 2016 - academic.oup.com
Celastrol is a bioactive compound derived from traditional Chinese medicinal herbs of the
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …
Celastraceae family. Celastrol is known to possess anti-inflammatory and anti-oxidant …
Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis*♦
Pharmacological inhibition of Hsp90 is an exciting option for cancer therapy. The clinical
efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone …
efficacy of Hsp90 inhibitors is, however, less than expected. Binding of the co-chaperone …
Celastrol and its role in controlling chronic diseases
SH Venkatesha, KD Moudgil - Anti-inflammatory Nutraceuticals and …, 2016 - Springer
Celastrol, a triterpenoid derived from traditional Chinese medicinal plants, has anti-
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …
inflammatory, antioxidant, and anticancer activities. Celastrol has shown …
Lycopene inhibits TNF-α-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion
Inflammatory mediators such as TNF-α and interleukin (IL)-1β, and IL-8, which can enhance
binding of low-density lipoprotein (LDL) to endothelium and upregulate expression of …
binding of low-density lipoprotein (LDL) to endothelium and upregulate expression of …
[PDF][PDF] Cancer chemoprevention by flavonoids, dietary polyphenols and terpenoids
The world population is aging, and cancer is always considered to be one of the major
causes of death all over the globe. The advent of recent drug-targeted therapies …
causes of death all over the globe. The advent of recent drug-targeted therapies …