Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Osteochondral defect repair in osteoarthritis (OA) remains an unsolved clinical problem due
to the lack of enough seed cells in the defect and chronic inflammation in the joint. To …

Stem cells (SCs) hold great promise for cell therapy, tissue engineering, and regenerative
medicine as well as pharmaceutical and biotechnological applications. They have the …

Hyaluronic acid (HA), an immunoneutral polysaccharide that is ubiquitous in the human
body, is crucial for many cellular and tissue functions and has been in clinical use for over …

The cellular microenvironment plays an integral role in improving the function of
microengineered tissues. Control of the microarchitecture in engineered tissues can be …

Adipose‐derived stem cells (ASCs) are a mesenchymal stem cell source with properties of
self‐renewal and multipotential differentiation. Compared to bone marrow‐derived stem …

Mesenchymal stem cells (MSCs) are multipotent stem cells. Although they were originally
identified in bone marrow and described as 'marrow stromal cells', they have since been …

Proper tissue function and regeneration rely on robust spatial and temporal control of
biophysical and biochemical microenvironmental cues through mechanisms that remain …