Models of shear-induced platelet activation and numerical implementation with computational fluid dynamics approaches
Shear-induced platelet activation is one of the critical outcomes when blood is exposed to
elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus …
elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus …
Mathematical and computational modeling of device-induced thrombosis
Given the extensive and routine use of cardiovascular devices, a major limiting factor to their
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …
Multi-indicator analysis of mechanical blood damage with five clinical ventricular assist devices
Purpose Device-induced blood damage contributes the hemolysis, thrombosis and bleeding
complications in patients supported with ventricular assist device (VAD). This study aims to …
complications in patients supported with ventricular assist device (VAD). This study aims to …
A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution
Modeling thrombus growth in pathological flows allows evaluation of risk under patient-
specific pharmacological, hematological, and hemodynamical conditions. We have …
specific pharmacological, hematological, and hemodynamical conditions. We have …
Development and validation of a mathematical model for evaluating shear-induced damage of von Willebrand factor
Y Li, Y Xi, H Wang, A Sun, L Wang, X Deng… - Computers in Biology …, 2023 - Elsevier
Purpose To develop a mathematical model for predicting shear-induced von Willebrand
factor (vWF) function modification which can be used to guide ventricular assist devices …
factor (vWF) function modification which can be used to guide ventricular assist devices …
A mathematical model for assessing shear induced bleeding risk
Y Li, H Wang, Y Xi, A Sun, L Wang, X Deng… - Computer Methods and …, 2023 - Elsevier
Purpose The objective of this study is to develop a bleeding risk model for assessing device-
induced bleeding risk in patients supported with blood contact medical devices (BCMDs) …
induced bleeding risk in patients supported with blood contact medical devices (BCMDs) …
Characterization of dynamic adsorption regimes in synthetic and natural porous structures using lattice Boltzmann simulations
This paper presents the first systematic study on the characterization of dynamic adsorption
regimes of gas in porous media using the ratio of inter-to intraparticle diffusion coefficients …
regimes of gas in porous media using the ratio of inter-to intraparticle diffusion coefficients …
Bio-inspired microfluidics: A review
Biomicrofluidics, a subdomain of microfluidics, has been inspired by several ideas from
nature. However, while the basic inspiration for the same may be drawn from the living …
nature. However, while the basic inspiration for the same may be drawn from the living …
A homogenized two-phase computational framework for meso-and macroscale blood flow simulations
Abstract Background and Objective Owing to the complexity of physics linked with blood flow
and its associated phenomena, appropriate modeling of the multi-constituent rheology of …
and its associated phenomena, appropriate modeling of the multi-constituent rheology of …
Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity
T Feaugas, G Newman, ST Calzuola… - Frontiers in …, 2023 - frontiersin.org
Blood-circulating devices such as oxygenators have offered life-saving opportunities for
advanced cardiovascular and pulmonary failures. However, such systems are limited in the …
advanced cardiovascular and pulmonary failures. However, such systems are limited in the …