Models of shear-induced platelet activation and numerical implementation with computational fluid dynamics approaches

D Han, J Zhang, BP Griffith… - Journal of …, 2022 - asmedigitalcollection.asme.org
Shear-induced platelet activation is one of the critical outcomes when blood is exposed to
elevated shear stress. Excessively activated platelets in the circulation can lead to thrombus …

Mathematical and computational modeling of device-induced thrombosis

KB Manning, F Nicoud, SM Shea - Current opinion in biomedical …, 2021 - Elsevier
Given the extensive and routine use of cardiovascular devices, a major limiting factor to their
success is the thrombotic rate that occurs. This poses direct risk to the patient and requires …

Multi-indicator analysis of mechanical blood damage with five clinical ventricular assist devices

Y Li, H Wang, Y Xi, A Sun, X Deng, Z Chen… - Computers in biology and …, 2022 - Elsevier
Purpose Device-induced blood damage contributes the hemolysis, thrombosis and bleeding
complications in patients supported with ventricular assist device (VAD). This study aims to …

A three-dimensional multiscale model for the prediction of thrombus growth under flow with single-platelet resolution

KN Shankar, Y Zhang, T Sinno… - PLoS computational …, 2022 - journals.plos.org
Modeling thrombus growth in pathological flows allows evaluation of risk under patient-
specific pharmacological, hematological, and hemodynamical conditions. We have …

Development and validation of a mathematical model for evaluating shear-induced damage of von Willebrand factor

Y Li, Y Xi, H Wang, A Sun, L Wang, X Deng… - Computers in Biology …, 2023 - Elsevier
Purpose To develop a mathematical model for predicting shear-induced von Willebrand
factor (vWF) function modification which can be used to guide ventricular assist devices …

A mathematical model for assessing shear induced bleeding risk

Y Li, H Wang, Y Xi, A Sun, L Wang, X Deng… - Computer Methods and …, 2023 - Elsevier
Purpose The objective of this study is to develop a bleeding risk model for assessing device-
induced bleeding risk in patients supported with blood contact medical devices (BCMDs) …

Characterization of dynamic adsorption regimes in synthetic and natural porous structures using lattice Boltzmann simulations

TR Zakirov, MA Varfolomeev, C Yuan - Chemical Engineering Research …, 2023 - Elsevier
This paper presents the first systematic study on the characterization of dynamic adsorption
regimes of gas in porous media using the ratio of inter-to intraparticle diffusion coefficients …

Bio-inspired microfluidics: A review

K Raj M, J Priyadarshani, P Karan… - …, 2023 - pubs.aip.org
Biomicrofluidics, a subdomain of microfluidics, has been inspired by several ideas from
nature. However, while the basic inspiration for the same may be drawn from the living …

A homogenized two-phase computational framework for meso-and macroscale blood flow simulations

A Karmakar, GW Burgreen, G Rydquist… - Computer Methods and …, 2024 - Elsevier
Abstract Background and Objective Owing to the complexity of physics linked with blood flow
and its associated phenomena, appropriate modeling of the multi-constituent rheology of …

Design of artificial vascular devices: Hemodynamic evaluation of shear-induced thrombogenicity

T Feaugas, G Newman, ST Calzuola… - Frontiers in …, 2023 - frontiersin.org
Blood-circulating devices such as oxygenators have offered life-saving opportunities for
advanced cardiovascular and pulmonary failures. However, such systems are limited in the …