Inhibition of FGF‐FGFR and VEGF‐VEGFR signalling in cancer treatment

G Liu, T Chen, Z Ding, Y Wang, Y Wei, X Wei - Cell proliferation, 2021 - Wiley Online Library
The sites of targeted therapy are limited and need to be expanded. The FGF‐FGFR
signalling plays pivotal roles in the oncogenic process, and FGF/FGFR inhibitors are a …

Anaplastic thyroid carcinoma: an update

A Jannin, A Escande, A Al Ghuzlan, P Blanchard… - Cancers, 2022 - mdpi.com
Simple Summary Anaplastic thyroid carcinoma (ATC) has a dismal prognostic.
Chemotherapy and radiotherapy are the mainstem options for patients with ATC. In selected …

2021 American thyroid association guidelines for management of patients with anaplastic thyroid cancer: American thyroid association anaplastic thyroid cancer …

KC Bible, E Kebebew, J Brierley, JP Brito… - Thyroid, 2021 - liebertpub.com
Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid
cancer. Since the guidelines for the management of ATC by the American Thyroid …

[HTML][HTML] Dabrafenib plus trametinib in patients with BRAF V600E-mutant anaplastic thyroid cancer: updated analysis from the phase II ROAR basket study

V Subbiah, RJ Kreitman, ZA Wainberg, JY Cho… - Annals of …, 2022 - Elsevier
Background Combined therapy with dabrafenib plus trametinib was approved in several
countries for treatment of BRAF V600E-mutant anaplastic thyroid cancer (ATC) based on an …

Combination of lenvatinib and pembrolizumab is an effective treatment option for anaplastic and poorly differentiated thyroid carcinoma

C Dierks, J Seufert, K Aumann, J Ruf, C Klein, S Kiefer… - Thyroid, 2021 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) and metastatic poorly differentiated thyroid
carcinomas (PDTCs) are rare aggressive malignancies with poor overall survival (OS) …

Inhibition of FGFR reactivates IFNγ signaling in tumor cells to enhance the combined antitumor activity of lenvatinib with anti-PD-1 antibodies

Y Adachi, H Kamiyama, K Ichikawa, S Fukushima… - Cancer research, 2022 - AACR
Combination therapies consisting of immune checkpoint inhibitors plus anti-VEGF therapy
show enhanced antitumor activity and are approved treatments for patients with renal cell …

Open-label, single-arm, multicenter, phase II trial of lenvatinib for the treatment of patients with anaplastic thyroid cancer

LJ Wirth, MS Brose, EJ Sherman, L Licitra… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a
poor prognosis and an unmet need for effective treatment, especially for patients without …

Molecular targets of tyrosine kinase inhibitors in thyroid cancer

P Fallahi, SM Ferrari, MR Galdiero, G Varricchi… - Seminars in cancer …, 2022 - Elsevier
Thyroid cancer (TC) is the eighth most frequently diagnosed cancer worldwide with a rising
incidence in the past 20 years. Surgery is the primary strategy of therapy for patients with …

Anlotinib in locally advanced or metastatic medullary thyroid carcinoma: a randomized, double-blind phase IIB trial

D Li, Y Chi, X Chen, M Ge, Y Zhang, Z Guo… - Clinical Cancer …, 2021 - AACR
Purpose: Medullary thyroid cancer (MTC) accounts for about 2% of all thyroid cancer, but
has a relatively poor prognosis compared with differentiated thyroid cancer. Anlotinib is a …

The revised clinical practice guidelines on the management of thyroid tumors by the Japan Associations of Endocrine Surgeons: Core questions and …

Y Ito, N Onoda, T Okamoto - Endocrine journal, 2020 - jstage.jst.go.jp
Abstract The Japan Associations of Endocrine Surgeons has developed the revised version
of the Clinical Practice Guidelines for Thyroid Tumors. This article describes the guidelines …