This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

A-type voltage-gated potassium (Kv) channels are major regulators of neuronal excitability
that have been mainly characterized in the central nervous system. By contrast, there is a …

Neuropathic pain is a refractory disease characterized by maladaptive changes in gene
transcription and translation in the sensory pathway. Long noncoding RNAs (lncRNAs) are …

For many experiments in the study of the peripheral nervous system, it would be useful to
genetically manipulate primary sensory neurons. We have compared vectors based on …

Neuropathic pain affects more than one million people across the globe. The quality of life of
people suffering from neuropathic pain has been considerably declining due to the …

Nerve injury-induced alternations of gene expression in primary sensory neurons of the
dorsal root ganglion (DRG) are molecular basis of neuropathic pain genesis. Transcription …

Neuropathic pain is a chronic condition that is often refractory to treatment with available
therapies and thus an unmet medical need. We have previously shown that the voltage …

The A118G SNP (single nucleotide polymorphism) of the hMOPR [human MOPR (μ opioid
receptor)] gene OPRM1 results in an amino acid substitution (N40D). Subjects homozygous …

Background: Neuronal transduction by adeno-associated viral (AAV) vectors has been
demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of …

A lack of inhibition, particularly that mediated by gamma-amino butyric acid (GABA), the
main inhibitory transmitter of the central nervous system (CNS), is responsible for many pain …