Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Entropy and the brain: An overview

S Keshmiri - Entropy, 2020 - mdpi.com
Entropy is a powerful tool for quantification of the brain function and its information
processing capacity. This is evident in its broad domain of applications that range from …

Accuracy of EEG biomarkers in the detection of clinical outcome in disorders of consciousness after severe acquired brain injury: preliminary results of a pilot study …

F Di Gregorio, F La Porta, V Petrone, S Battaglia… - Biomedicines, 2022 - mdpi.com
Accurate outcome detection in neuro-rehabilitative settings is crucial for appropriate long-
term rehabilitative decisions in patients with disorders of consciousness (DoC). EEG …

Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation

LRB Spindler, AI Luppi, RM Adapa… - Proceedings of the …, 2021 - National Acad Sciences
Clinical research into consciousness has long focused on cortical macroscopic networks
and their disruption in pathological or pharmacological consciousness perturbation. Despite …

Consciousness-specific dynamic interactions of brain integration and functional diversity

AI Luppi, MM Craig, I Pappas, P Finoia… - Nature …, 2019 - nature.com
Prominent theories of consciousness emphasise different aspects of neurobiology, such as
the integration and diversity of information processing within the brain. Here, we combine …

Temporal circuit of macroscale dynamic brain activity supports human consciousness

Z Huang, J Zhang, J Wu, GA Mashour, AG Hudetz - Science advances, 2020 - science.org
The ongoing stream of human consciousness relies on two distinct cortical systems, the
default mode network and the dorsal attention network, which alternate their activity in an …

The curing coma campaign: framing initial scientific challenges—proceedings of the first curing coma campaign scientific advisory council meeting

JJ Provencio, JC Hemphill, J Claassen, BL Edlow… - Neurocritical care, 2020 - Springer
Coma and disordered consciousness are common manifestations of acute neurological
conditions and are among the most pervasive and challenging aspects of treatment in …

Advanced neuroimaging in traumatic brain injury: an overview

LGF Smith, E Milliron, ML Ho, HH Hu, J Rusin… - Neurosurgical …, 2019 - thejns.org
Traumatic brain injury (TBI) is a common condition with many potential acute and chronic
neurological consequences. Standard initial radiographic evaluation includes noncontrast …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

Update on neuroimaging in disorders of consciousness

LRD Sanz, A Thibaut, BL Edlow… - Current opinion in …, 2021 - journals.lww.com
Each neuroimaging technique conveys advantages and pitfalls to assess consciousness.
We recommend a multimodal approach in which complementary techniques provide …