Despite sleep's fundamental role in maintaining and improving physical and mental health,
many people get less than the recommended amount of sleep or suffer from sleeping …

Sleep disturbance is the most prominent symptom in depressive patients and was formerly
regarded as a main secondary manifestation of depression. However, many longitudinal …

Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the
United States. BZDs are a class of psychoactive drugs known for their depressant effect on …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on the management of chronic …

Background: Because psychological approaches are likely to produce sustained benefits
without the risk for tolerance or adverse effects associated with pharmacologic approaches …

Purpose Insomnia is problematic for older adults. After behavioral modifications fail to show
adequate response, pharmacologic options are used. The pharmacokinetics of agents used …

Studies based on databases, medical records and registers are used extensively today in
epidemiological research. Despite the increasing use, no developed methodological …

Impaired sleep quality and quantity are associated with future morbidity and mortality.
Exercise may be an effective non-pharmacological intervention to improve sleep, however …

Various adverse events resulting from, or associated with, benzodiazepine and/or Z-drug
use have been extensively reported on and discussed in great detail within the biomedical …

Background: Pharmacologic interventions are often prescribed for insomnia disorder.
Purpose: To assess the benefits, harms, and comparative effectiveness of pharmacologic …