Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which
mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key …

Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …

Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the
world's population. The etiology of RA remains unknown. It is considered to occur in the …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial
hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts …

Rheumatoid arthritis (RA) is an immune-mediated disease involving chronic low-grade
inflammation that may progressively lead to joint destruction, deformity, disability and even …

Rheumatoid arthritis (RA) is characterized by immune dysfunctions and chronic
inflammation that mainly affects diarthrodial joints. Genetics has long been surveyed in …

The etiology of autoimmune diseases remains largely unknown. Concordance rates in
monozygotic twins are lower than 50% while genome-wide association studies propose …

Background Histone deacetylase inhibitors (HDACi) display potent therapeutic efficacy in
animal models of arthritis and suppress inflammatory cytokine production in rheumatoid …

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B,
which have sparse CpG islands, is poorly understood in the context of musculoskeletal …

B cells have a critical role in the initiation and acceleration of autoimmune diseases,
especially those mediated by autoantibodies. In the peripheral lymphoid system, mature B …