Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

The role of macrophage migration inhibitory factor (MIF) in autoimmunity is underscored by
data showing that common functional polymorphisms in MIF are associated with disease …

Abstract CD74 (MHC class II invariant chain, Ii) is a non-polymorphic type II transmembrane
glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a …

Wound healing after an injury is essential for life. An in-depth understanding of the healing
process is necessary to ultimately improve the currently limited treatment options for patients …

Introduction. Macrophage migration inhibitory factor (MIF) is a pleiotropic inflammatory
cytokine with upstream regulatory roles in innate and adaptive immunity and is implicated in …

The application of tumor immunotherapy to glioblastoma (GBM) is limited by an
unprecedented degree of immune suppression due to factors that include high numbers of …

Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus
erythematosus. The general consensus is that 60% of lupus patients will develop clinically …

D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the
macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed …

Tumor stromal alternatively activated macrophages are important determinants of antitumor
T lymphocyte responses, intratumoral neovascularization, and metastatic dissemination. Our …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst
formation, inflammation, and fibrosis. Macrophages infiltrate cystic kidneys, but the role of …