Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
Comprehensive investigation of pathway enrichment methods for functional interpretation of LC–MS global metabolomics data
Background: Global or untargeted metabolomics is widely used to comprehensively
investigate metabolic profiles under various pathophysiological conditions such as …
investigate metabolic profiles under various pathophysiological conditions such as …
[HTML][HTML] Atlas of plasma NMR biomarkers for health and disease in 118,461 individuals from the UK Biobank
H Julkunen, A Cichońska, M Tiainen, H Koskela… - Nature …, 2023 - nature.com
Blood lipids and metabolites are markers of current health and future disease risk. Here, we
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
describe plasma nuclear magnetic resonance (NMR) biomarker data for 118,461 …
Artificial intelligence-powered electronic skin
Skin-interfaced electronics is gradually changing medical practices by enabling continuous
and non-invasive tracking of physiological and biochemical information. With the rise of big …
and non-invasive tracking of physiological and biochemical information. With the rise of big …
A physicochemical-sensing electronic skin for stress response monitoring
Approaches to quantify stress responses typically rely on subjective surveys and
questionnaires. Wearable sensors can potentially be used to continuously monitor stress …
questionnaires. Wearable sensors can potentially be used to continuously monitor stress …
[HTML][HTML] Plasma proteomic profiles predict individual future health risk
Developing a single-domain assay to identify individuals at high risk of future events is a
priority for multi-disease and mortality prevention. By training a neural network, we …
priority for multi-disease and mortality prevention. By training a neural network, we …
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
G Xourafa, M Korbmacher, M Roden - Nature Reviews Endocrinology, 2024 - nature.com
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …
Metabolomic epidemiology offers insights into disease aetiology
Metabolomic epidemiology is the high-throughput study of the relationship between
metabolites and health-related traits. This emerging and rapidly growing field has improved …
metabolites and health-related traits. This emerging and rapidly growing field has improved …
Efficient plasma metabolic fingerprinting as a novel tool for diagnosis and prognosis of gastric cancer: a large-scale, multicentre study
Objective Metabolic biomarkers are expected to decode the phenotype of gastric cancer
(GC) and lead to high-performance blood tests towards GC diagnosis and prognosis. We …
(GC) and lead to high-performance blood tests towards GC diagnosis and prognosis. We …
Efficient metabolic fingerprinting of follicular fluid encodes ovarian reserve and fertility
Ovarian reserve (OR) and fertility are critical in women's healthcare. Clinical methods for
encoding OR and fertility rely on the combination of tests, which cannot serve as a multi …
encoding OR and fertility rely on the combination of tests, which cannot serve as a multi …