Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy.
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …

BRD4-NUT, a driver fusion mutant in rare and highly aggressive NUT carcinoma, acts in
aberrant transcription of anti-differentiation genes by recruiting histone acetyltransferase …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

NUT carcinoma is a rare, aggressive cancer defined by rearrangements of the NUTM1 gene.
No routinely effective treatments of NUT carcinoma exist, despite harboring a targetable …

YAP1-NUTM1 fusion transcripts have been recently reported in poroma and porocarcinoma.
NUTM1 translocation can be screened by nuclear protein in testis (NUT) …

Male germ cells undergo an extreme but fascinating process of chromatin remodeling that
begins in the testis during the last phase of spermatogenesis and continues through …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Poroma is a benign sweat gland tumour showing morphological features recapitulating the
superficial portion of the eccrine sweat coil. A subset of poromas may transform into …

In addition to acetylation, histones are modified by a series of competing longer-chain
acylations. Most of these acylation marks are enriched and co-exist with acetylation on …