Tinnitus displays many features suggestive of plastic changes in the nervous system. These
can be categorized based on the types of manipulations that induce them. We have …

We consider the impact of purinergic signaling on the physiology of the special senses of
vision, smell, taste and hearing. Purines (particularly ATP and adenosine) act as …

The mammalian cochlea is innervated by two classes of sensory neurons. Type I neurons
make up 90–95% of the cochlear nerve and contact single inner hair cells to provide …

Mammalian cochlear spiral ganglion neurons (SGNs) encode sound with microsecond
precision. Spike triggering relies upon input from a single ribbon-type active zone of a …

Background The mechanisms that consolidate neural circuitry are a major focus of
neuroscience. In the mammalian cochlea, the refinement of spiral ganglion neuron (SGN) …

The adult mammalian cochlea receives dual afferent innervation: the inner sensory hair cells
are innervated exclusively by type I spiral ganglion neurons (SGN), whereas the sensory …

The dynamic adjustment of hearing sensitivity and frequency selectivity is mediated by the
medial olivocochlear efferent reflex, which suppresses the gain of the 'cochlear amplifier'in …

The mammalian cochlea is the sensory organ of hearing with a delicate, highly organised
structure that supports unique operating mechanisms. ATP release from the secretory …

Type II cochlear afferents receive glutamatergic synaptic excitation from outer hair cells
(OHCs) in the rat cochlea. However, it remains uncertain whether this connection is capable …

Atypical medial olivocochlear (MOC) feedback from brain stem to cochlea has been
proposed to play a role in tinnitus, but even well-constructed tests of this idea have yielded …