Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Treating cancer through inhibition of nuclear export is one of the best examples of basic
research translation into clinical application. Nuclear export factor chromosomal region …

The retinoblastoma protein gene RB-1 is mutated in one-third of human tumors. Its protein
product, pRB (retinoblastoma protein), functions as a transcriptional coregulator in many …

The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibiting
the E2F family of transcription factors that govern cell-cycle progression. However, it remains …

The changes from normal cells to cancer cells are primarily regulated by genome instability,
which foster hallmark functions of cancer through multiple mechanisms including protein …

Spatiotemporally dynamic microtubule acetylation underlies diverse physiological and
pathological events. Despite its ubiquity, the molecular mechanisms that regulate the sole …

Bioactive food compounds (BFCs) exhibit potential anticarcinogenic effects that deserve to
be explored. Butyric acid (BA) is considered a promising BFC and has been used in clinical …

Although the retinoblastoma protein (Rb) functions as a checkpoint in the cell cycle, it also
regulates differentiation. It has recently been shown that Rb is acetylated during …

Purpose/Aim of the study Retinoblastoma (Rb) is a rare form of pediatric cancer that
develops from retina cells. Bilateral and some unilateral forms of Rb are associated with …

Lysine acetylation is a critical post-translation modification that can impact a protein's
localization, stability, and function. Originally thought to only occur on histones, we now …