Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …

On the basis of many literature measurements, a critical overview is given on essential
noncovalent interactions in synthetic supramolecular complexes, accompanied by analyses …

The specific recognition of protein surface elements is a fundamental challenge in the life
sciences. New developments in this field will form the basis of advanced therapeutic …

Molecular tweezers represent the first class of artificial receptor molecules that have made
the way from a supramolecular host to a drug candidate with promising results in animal …

Protein amyloid aggregation has been widely observed to occur and plays important roles in
both physiological processes and pathological diseases. Remarkably, amyloid aggregates …

Lysine-selective molecular tweezers (MTs) are supramolecular host molecules displaying a
remarkably broad spectrum of biologic activities. MTs act as inhibitors of the self-assembly …

Recent work on α-synuclein has shown that aggregation is controlled kinetically by the rate
of reconfiguration of the unstructured chain, such that the faster the reconfiguration, the …

Broad-spectrum antivirals are powerful weapons against dangerous viruses where no
specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered …

The early oligomerization of amyloid β-protein (Aβ) has been shown to be an important
event in the pathology of Alzheimer's disease (AD). Designing small molecule inhibitors …

Semen is the main vector for HIV transmission and contains amyloid fibrils that enhance viral
infection. Available microbicides that target viral components have proven largely ineffective …