Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Proteostasis of islet amyloid polypeptide: a molecular perspective of risk factors and protective strategies for type II diabetes
The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …
Lipid-chaperone hypothesis: A common molecular mechanism of membrane disruption by intrinsically disordered proteins
An increasing number of human diseases has been shown to be linked to aggregation and
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
amyloid formation by intrinsically disordered proteins (IDPs). Amylin, amyloid-β, and α …
Amyloidogenic protein–membrane interactions: mechanistic insight from model systems
SM Butterfield, HA Lashuel - Angewandte Chemie International …, 2010 - Wiley Online Library
The toxicity of amyloid‐forming proteins is correlated with their interactions with cell
membranes. Binding events between amyloidogenic proteins and membranes result in …
membranes. Binding events between amyloidogenic proteins and membranes result in …
Islet amyloid polypeptide: structure, function, and pathophysiology
R Akter, P Cao, H Noor, Z Ridgway… - Journal of diabetes …, 2016 - Wiley Online Library
The hormone islet amyloid polypeptide (IAPP, or amylin) plays a role in glucose
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
homeostasis but aggregates to form islet amyloid in type‐2 diabetes. Islet amyloid formation …
The magic of bicelles lights up membrane protein structure
UHN Dürr, M Gildenberg, A Ramamoorthy - Chemical reviews, 2012 - ACS Publications
Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …
biological processes, present one of the paramount challenges in biophysics today …
Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective
JR Brender, S Salamekh… - Accounts of chemical …, 2012 - ACS Publications
The aggregation of proteins is tightly controlled in living systems, and misfolded proteins are
normally removed before aggregation of the misfolded protein can occur. But for reasons not …
normally removed before aggregation of the misfolded protein can occur. But for reasons not …
Misfolded proteins in Alzheimer's disease and type II diabetes
AS DeToma, S Salamekh, A Ramamoorthy… - Chemical Society …, 2012 - pubs.rsc.org
This tutorial review presents descriptions of two amyloidogenic proteins, amyloid-β (Aβ)
peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated …
peptides and islet amyloid polypeptide (IAPP), whose misfolding propensities are implicated …
Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …
their development. This is the case of important neurodegenerative diseases such as …
Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation
Mechanistic understanding of nucleation dependent polymerization by α-synuclein (α-Syn)
into toxic oligomers and amyloids is important for the drug development against Parkinson's …
into toxic oligomers and amyloids is important for the drug development against Parkinson's …