Deciphering how the regulatory DNA sequence of a gene dictates its expression in
response to intra and extracellular cues is one of the leading challenges in modern …

MicroRNAs are small noncoding RNAs that regulate genes post-transciptionally by binding
and degrading target eukaryotic mRNAs. We use a quantitative model to study gene …

The process of transcription initiation and elongation are primary points of control in the
regulation of gene expression. Although biochemical studies have uncovered the …

Burst-like synthesis of protein is a significant source of cell-to-cell variability in protein levels.
Negative feedback is a common example of a regulatory mechanism by which such …

In this paper we study an important global regulation mechanism of transcription of
biological cells using specific macro-molecules, 6S RNAs. The functional property of 6S …

Intrinsic noise, which arises in gene expression at low copy numbers, can be controlled by
diverse regulatory motifs, including feedforward loops. Here, we study an example of a …

Transcription is the dominant point of control of gene expression. Biochemical studies have
revealed key molecular components of transcription and their interactions, but the dynamics …

Processive proteases, such as ClpXP in E. coli, are conserved enzyme assemblies that can
recognize and rapidly degrade proteins. These proteases are used for a number of …

Small regulatory RNAs (sRNAs) in bacteria regulate many important cellular activities under
normal conditions and in response to stress. Many sRNAs bind to the mRNA targets at or …

Cells use various regulatory motifs, including feedforward loops, to control the intrinsic noise
that arises in gene expression at low copy numbers. Here we study one such system, which …