The electromechanical function of the heart involves complex, coordinated activity over time
and space. Life-threatening cardiac arrhythmias arise from asynchrony in these space–time …

Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop
fashion is necessary to establish causative links between biochemical processes within the …

Optogenetic technologies have transformed our ability to precisely control biological
processes in time and space. Yet, current eukaryotic optogenetic systems are limited by …

Mitochondrial respiration results in an electrochemical proton gradient, or protonmotive force
(pmf), across the mitochondrial inner membrane. The pmf is a form of potential energy …

Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which
consequently plays a central role in enhancing metabolic health. Despite this, the precise …

Abstract Hydrogen peroxide (H2O2) functions as a second messenger to signal metabolic
distress through highly compartmentalized production in mitochondria. The dynamics of …

The design of the energy metabolism system in striated muscle remains a major area of
investigation. Here, we review our current understanding and emerging hypotheses …

Over the past few years, we have seen an explosion of novel genetically encoded tools for
measuring and manipulating metabolism in live cells and animals. Here, we will review the …

The first member and eponym of the rhodopsin family was identified in the 1930s as the
visual pigment of the rod photoreceptor cell in the animal retina. It was found to be a …

Axonal mitochondrial quality is essential for neuronal health and functions. Compromised
mitochondrial quality, reflected by loss of membrane potential, collapse of ATP production …