The Physiology of Enteric Glia

J Gonzales, BD Gulbransen - Annual Review of Physiology, 2024 - annualreviews.org
Enteric glia are the partners of neurons in the enteric nervous system throughout the
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …

The role of neuroinflammation in the transition of acute to chronic pain and the opioid-induced hyperalgesia and tolerance

M Echeverria-Villalobos, V Tortorici, BE Brito… - Frontiers in …, 2023 - frontiersin.org
Current evidence suggests that activation of glial and immune cells leads to increased
production of proinflammatory mediators, creating a neuroinflammatory state …

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

L van Baarle, V De Simone, L Schneider… - Nature …, 2024 - nature.com
Enteric glia have been recently recognized as key components of the colonic tumor
microenvironment indicating their potential role in colorectal cancer pathogenesis. Although …

From diversity to disease: unravelling the role of enteric glial cells

S Santhosh, L Zanoletti, LA Stamp, MM Hao… - Frontiers in …, 2024 - frontiersin.org
Enteric glial cells (EGCs) are an essential component of the enteric nervous system (ENS)
and play key roles in gastrointestinal development, homeostasis, and disease. Derived from …

Guardians of the gut: influence of the enteric nervous system on the intestinal epithelial barrier

M Bubeck, C Becker, JV Patankar - Frontiers in Medicine, 2023 - frontiersin.org
The intestinal mucosal surface forms one of the largest areas of the body, which is in direct
contact with the environment. Co-ordinated sensory functions of immune, epithelial, and …

β-adrenergic signaling triggers enteric glial reactivity and acute enteric gliosis during surgery

P Leven, R Schneider, L Schneider, S Mallesh… - Journal of …, 2023 - Springer
Background Enteric glia contribute to the pathophysiology of various intestinal immune-
driven diseases, such as postoperative ileus (POI), a motility disorder and common …

Down-regulation of ABCA7 in human microglia, astrocyte and THP-1 cell lines by cholesterol depletion, IL-1β and TNFα, or PMA

JP Wiener, S Desire, V Garliyev, N Lyssenko III… - Cells, 2023 - mdpi.com
Adenosine triphosphate-binding cassette transporter subfamily A member 7 (ABCA7) is a
major risk factor for Alzheimer's disease. Human neural cell lines were used to investigate …

BQ788 reveals glial ETB receptor modulation of neuronal cholinergic and nitrergic pathways to inhibit intestinal motility: Linked to postoperative ileus

E Mazzotta, I Grants… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose ET‐1 signalling modulates intestinal motility and inflammation, but
the role of ET‐1/ETB receptor signalling is poorly understood. Enteric glia modulate normal …

Enteric neuro-immune interactions in intestinal health and disease

L van Baarle, M Stakenborg, G Matteoli - Seminars in Immunology, 2023 - Elsevier
The enteric nervous system is an autonomous neuronal circuit that regulates many
processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of …

Mini-Review: Enteric Glial Cell Reactions to Inflammation and Potential Therapeutic Implications for GI Diseases, Motility Disorders and Abdominal Pain

A Linan-Rico, F Ochoa-Cortes, R Schneider… - Neuroscience …, 2023 - Elsevier
Enteric glial cells are emerging as critical players in the regulation of intestinal motility,
secretion, epithelial barrier function, and gut homeostasis in health and disease. Enteric glia …