The skeleton is a highly dynamic tissue whose structure relies on the balance between bone
deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast …

The rising incidence of metabolic diseases worldwide has prompted renewed interest in the
study of intermediary metabolism and cellular bioenergetics. The application of modern …

Biological processes utilize energy and therefore must be prioritized based on fuel
availability. Bone is no exception to this, and the benefit of remodeling when necessary …

Mutations within the gene encoding for the chloride ion channel cystic fibrosis
transmembrane conductance regulator (CFTR) results in cystic fibrosis (CF), the most …

Peroxisome proliferator–activated receptor γ (PPARγ) is a master regulator of energy
metabolism. In bone, it is known to regulate osteoblast differentiation and osteoclast activity …

Type 2 diabetes mellitus is now a worldwide health problem with increasing prevalence.
Mounting efforts have been made to treat, prevent and predict this chronic disease. In recent …

Neural pathways are now a well-appreciated factor in the regulatory milieu controlling the
maintenance of bone mass. A number of neural pathways from the brain to bone have been …

Although the brain is well established as a master regulator of homeostasis in peripheral
tissues, central regulation of bone mass represents a novel and rapidly expanding field of …

Increased neuropeptide Y (NPY) expression occurred in the glucocorticoid-induced
osteoporotic skeleton. NPY knockout mice exhibited a minor response to the glucocorticoid …

Obesity and osteoporosis have become major public health challenges worldwide. The
brain is well established as a pivotal regulator of energy homeostasis, appetite and fuel …