Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects
S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …
Vitamin D and cardiovascular disease: current evidence and future perspectives
N Cosentino, J Campodonico, V Milazzo, M De Metrio… - Nutrients, 2021 - mdpi.com
Vitamin D deficiency is a prevalent condition, occurring in about 30–50% of the population,
observed across all ethnicities and among all age groups. Besides the established role of …
observed across all ethnicities and among all age groups. Besides the established role of …
Vitamin D and cancer: an historical overview of the epidemiology and mechanisms
This is a narrative review of the evidence supporting vitamin D's anticancer actions. The first
section reviews the findings from ecological studies of cancer with respect to indices of solar …
section reviews the findings from ecological studies of cancer with respect to indices of solar …
Extraskeletal actions of vitamin D
DD Bikle - Annals of the New York academy of sciences, 2016 - Wiley Online Library
The vitamin D receptor (VDR) is found in nearly all, if not all, cells in the body. The enzyme
that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1 …
that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1 …
Targeting microRNAs in cancer gene therapy
W Ji, B Sun, C Su - Genes, 2017 - mdpi.com
MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in
regulating gene expression by targeting multiple molecules. Early studies have shown that …
regulating gene expression by targeting multiple molecules. Early studies have shown that …
Cancer hallmarks and microRNAs: the therapeutic connection
K Van Roosbroeck, GA Calin - Advances in cancer research, 2017 - Elsevier
Human cancers are characterized by a number of hallmarks, including sustained
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …
proliferative signaling, evasion of growth suppressors, activated invasion and metastasis …
miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6
C Lei, F Du, L Sun, T Li, T Li, Y Min, A Nie, X Wang… - Cell death & …, 2017 - nature.com
Metastasis is a major clinical obstacle responsible for the high mortality and poor prognosis
of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by …
of gastric cancer (GC). MicroRNAs (miRNAs) are critical mediators of metastasis that act by …
Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145
H Lu, Y He, L Lin, Z Qi, L Ma, L Li, Y Su - Tumor Biology, 2016 - Springer
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA playing
oncogenic role in several cancers, including cervical cancer. However, its role in …
oncogenic role in several cancers, including cervical cancer. However, its role in …
MALAT1 modulates TGF-β1-induced endothelial-to-mesenchymal transition through downregulation of miR-145
Y Xiang, Y Zhang, Y Tang, Q Li - Cellular physiology and biochemistry, 2017 - karger.com
Abstract Background/Aims: Endothelial-to-mesenchymal transition (EndMT) plays significant
roles under various pathological conditions including cardiovascular diseases, fibrosis, and …
roles under various pathological conditions including cardiovascular diseases, fibrosis, and …
[HTML][HTML] Emerging roles of miR-145 in gastrointestinal cancers: A new paradigm
Gastrointestinal (GI) carcinomas are a group of cancers affecting the GI tract and digestive
organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon …
organs, such as the gastric, liver, bile ducts, pancreas, small intestine, esophagus, colon …