Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) is a pleiotropic janus-faced molecule synthesized by nitric oxide synthases
(NOS) which plays a critical role in a number of physiological and pathological processes in …

There is evidence that L‐tyrosine and L‐dihydroxyphenylalanine (L‐DOPA), besides serving
as substrates and intermediates of melanogenesis, are also bioregulatory agents acting not …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

Nitrosative stress, as an important oxygen metabolism disorder, has been shown to be
closely associated with cardiovascular diseases, such as myocardial ischemia/reperfusion …

Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

Nitric oxide and other redox active molecules such as oxygen free radicals provide essential
signalling in diverse neuronal functions, but their excess production and insufficient …

Fourteen years after the discovery that mutations in Cu, Zn superoxide dismutase (SOD1)
cause a subset of familial amyotrophic lateral sclerosis (fALS), the mechanism by which …

Tyrosine nitration is a covalent post-translational protein modification derived from the
reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of …