Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

There is a long-standing interest in exploring the relationship between blood-based
biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in …

Exposure to stressful life events increases the risk for psychiatric disorders. Mechanistic
insight into the genetic factors moderating the impact of stress can increase our …

Background Anorexia nervosa (AN) is a psychiatric disorder with complex etiology, with a
significant portion of disease risk imparted by genetics. Traditional genome-wide association …

Results Identification of Allele-Specific Regulatory Elements Modulated by a Glucocorticoid
Receptor Agonist in Response to Stress Using STARR-seq. We conducted an enhancer …

PURPOSE A meta-analysis suggests a relationship between abnormal glucose metabolism
and primary open-angle glaucoma (POAG); however, the causal association between them …

Background Eating disorder (ED) symptoms are prevalent in the general population, but
their shared genetic underpinnings with psychiatric, metabolic, and anthropometric traits are …

BackgroundAnorexia nervosa (AN) is a psychiatric disorder associated with marked
morbidity. Whilst AN genetic studies could identify novel treatment targets, integration of …

Background Psychiatric disorders are emerging as a serious public health hazard,
influencing an increasing number of individuals worldwide. However, the effect of modifiable …