In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a
homopentameric cation channel that is important for virus pathogenicity. Here we report a …

Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Abstract Structure determination of membrane proteins is critical to the molecular
understanding of many life processes, yet it has historically been a technically challenging …

Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–
environment, cell–cell and virus–host communication; nutrients intake; export of toxic …

The emergence in late 2019 of the coronavirus SARS-CoV-2 has resulted in the
breakthrough of the COVID-19 pandemic that is presently affecting a growing number of …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

Toll-like receptors (TLRs) are the important participants of the innate immune response.
Their spatial organization is well studied for the ligand-binding domains, while a lot of …