Carbohydrates are the most abundant and one of the most important biomacromolecules in
Nature. Except for energy-related compounds, carbohydrates can be roughly divided into …

Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …

This review article highlights the strategies to successfully perform an efficient solid-phase
synthesis of complex peptides including posttranslational modifications, fluorescent labels …

Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been
extremely successful in preventing bacterial infections. The glycan antigens for the …

The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

Tumor-associated carbohydrate antigens (TACA) result from the aberrant glycosylation that
is seen with transformation to a tumor cell. The carbohydrate antigens that have been found …

Carbohydrates have been shown to play important roles in biological processes. The pace
of development in carbohydrate research is, however, relatively slow due to the problems …

Based on important cell-biological and biochemical results concerning the structural
difference between membrane glycoproteins of normal epithelial cells and epithelial tumour …

In the development of vaccines for epithelial tumors, the key targets are MUC1 proteins,
which have a variable number of tandem repeats (VNTR) bearing tumor-associated …

Introduction: Glycoconjugate vaccines are among the safest and most efficacious vaccines
developed during the last 30 years. They are a potent tool for prevention of life-threatening …