Recent studies indicate that the mechanism of nasopharynx-associated lymphoid tissue
(NALT) organogenesis is different from that of other lymphoid tissues. NALT has an …

During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

Induced pluripotent stem cells (iPSC) have been generated from somatic cells by
introducing reprogramming factors. Integration of foreign genes into the host genome is a …

Gene therapy for cystic fibrosis (CF) lung disease requires efficient gene transfer to airway
epithelial cells after intralumenal delivery. Most gene transfer vectors so far tested have not …

Direct cardiac reprogramming holds great promise for regenerative medicine. We previously
generated directly reprogrammed induced cardiomyocyte-like cells (iCMs) by …

Replication-deficient viruses have been used most successfully in the field of gene therapy
because of their high transfection efficiency. However, the risk of insertional mutagenesis …

The production of induced pluripotent stem cells (iPSCs) represent a breakthrough in
regenerative medicine, providing new opportunities for understanding basic molecular …

Drug delivery to mucosal epithelia is severely limited by the mucus gel, which is a physical
diffusion barrier as well as an enzymatic barrier in some sites. Loading of drug into polymer …

Respiratory gene therapy has been considered for the treatment of a broad range of
pulmonary disorders. However, respiratory secretions form an important barrier towards the …

The generation of induced pluripotent stem cells (iPSCs) from differentiated mature cells is
one of the most promising technologies in the field of regenerative medicine. The ability to …