Alzheimer's disease and inflammaging
AM Kosyreva, AV Sentyabreva, IS Tsvetkov… - Brain sciences, 2022 - mdpi.com
Alzheimer's disease is one of the most common age-related neurodegenerative disorders.
The main theory of Alzheimer's disease progress is the amyloid-β cascade hypothesis …
The main theory of Alzheimer's disease progress is the amyloid-β cascade hypothesis …
The use of neuroimaging techniques in the early and differential diagnosis of dementia
L Chouliaras, JT O'Brien - Molecular Psychiatry, 2023 - nature.com
Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …
disease modifying treatment for any of the most common types of dementia such as …
Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration
Y Jiang, JJ Alam, SN Gomperts, P Maruff… - Nature …, 2022 - nature.com
Abstract The endosome-associated GTPase Rab5 is a central player in the molecular
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …
mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long …
[HTML][HTML] A reusable benchmark of brain-age prediction from M/EEG resting-state signals
Population-level modeling can define quantitative measures of individual aging by applying
machine learning to large volumes of brain images. These measures of brain age, obtained …
machine learning to large volumes of brain images. These measures of brain age, obtained …
Determinants of approved acetylcholinesterase inhibitor response outcomes in Alzheimer's disease: relevance for precision medicine in neurodegenerative diseases
Acetylcholinesterase inhibitors (ChEI) are the global standard of care for the symptomatic
treatment of Alzheimer's disease (AD) and show significant positive effects in …
treatment of Alzheimer's disease (AD) and show significant positive effects in …
Cholinergic white matter pathways along the Alzheimer's disease continuum
Previous studies have shown that the cholinergic nucleus basalis of Meynert and its white
matter projections are affected in Alzheimer's disease dementia and mild cognitive …
matter projections are affected in Alzheimer's disease dementia and mild cognitive …
(Dis‐) Connected dots in dementia with lewy bodies—a systematic review of connectivity studies
Studies on dementia with Lewy bodies (DLB) have mainly focused on the degeneration of
distinct cortical and subcortical regions related to the deposition of Lewy bodies. In view of …
distinct cortical and subcortical regions related to the deposition of Lewy bodies. In view of …
Mild cognitive impairment in dementia with Lewy bodies: an update and outlook
KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Dementia with Lewy bodies (DLB), the second most common degenerative neurocognitive
disorder after Alzheimer disease (AD), is frequently preceded by a period of mild cognitive …
disorder after Alzheimer disease (AD), is frequently preceded by a period of mild cognitive …
Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer's disease
Y Jiang, TS Yuan, YC Chen, P Guo, TH Lian… - Translational …, 2022 - Springer
Background Deep brain stimulation (DBS) of the nucleus basalis of Meynert (NBM) has
shown potential for the treatment of mild-to-moderate Alzheimer's disease (AD). However …
shown potential for the treatment of mild-to-moderate Alzheimer's disease (AD). However …
Cholinergic changes in Lewy body disease: implications for presentation, progression and subtypes
Cholinergic degeneration is significant in Lewy body disease, including Parkinson's
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …
disease, dementia with Lewy bodies, and isolated REM sleep behavior disorder. Extensive …