The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
A molecular view of kinetochore assembly and function
A Musacchio, A Desai - Biology, 2017 - mdpi.com
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …
The molecular basis for centromere identity and function
KL McKinley, IM Cheeseman - Nature reviews Molecular cell biology, 2016 - nature.com
The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …
meiosis. Although the functional importance of the centromere has been appreciated for …
Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Kinetochores assemble onto specialized centromeric CENP-A (centromere protein A)
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
nucleosomes (CENP-ANuc) to mediate attachments between chromosomes and the mitotic …
Nucleosome structure and function
RK McGinty, S Tan - Chemical reviews, 2015 - ACS Publications
When fully extended, one copy of the three billion base pair human genome reaches a
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …
length of over two meters. Yet, it must be packaged into the nucleus of a cell with an average …
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?
K Luger, ML Dechassa, DJ Tremethick - Nature reviews Molecular cell …, 2012 - nature.com
The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …
[PDF][PDF] The centromere: chromatin foundation for the kinetochore machinery
T Fukagawa, WC Earnshaw - Developmental cell, 2014 - cell.com
Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …
come to be defined as chromatin structures that establish the assembly site for the complex …
The kinetochore
IM Cheeseman - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
A critical requirement for mitosis is the distribution of genetic material to the two daughter
cells. The central player in this process is the macromolecular kinetochore structure, which …
cells. The central player in this process is the macromolecular kinetochore structure, which …
A map of nucleosome positions in yeast at base-pair resolution
The exact positions of nucleosomes along genomic DNA can influence many aspects of
chromosome function. However, existing methods for mapping nucleosomes do not provide …
chromosome function. However, existing methods for mapping nucleosomes do not provide …
Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome
RK McGinty, RC Henrici, S Tan - Nature, 2014 - nature.com
The Polycomb group of epigenetic enzymes represses expression of developmentally
regulated genes in many eukaryotes. This group includes the Polycomb repressive complex …
regulated genes in many eukaryotes. This group includes the Polycomb repressive complex …