Abstract microRNAs (miRNAs) are suggested to play substantial roles in regulating the
development and various physiologic functions of the central nervous system (CNS). These …

Flavonoids represent an important group of bioactive compounds derived from plant-based
foods and beverages with known biological activity in cells. From the modulation of …

Angiogenesis and metastasis play pivotal roles in the progression of cancer. We recently
discovered that crocin, a dietary carotenoid derived from the Himalayan crocus, inhibited the …

The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …

Being a transcription factor, NF-κB regulates gene expressions involving cell survival and
proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a …

The NF-κB signalling pathway is a major signalling cascade involved in the regulation of
inflammation and innate immunity. It is also increasingly recognised as a crucial player in …

Macrophages are attracted to developing tumors and can participate in immune surveillance
to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this …

Multiple myeloma, which ranks as the second most common hematological malignancy, is
known for its great genetic heterogeneity. One pathway, however, stands out in this diverse …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is the third
highest among cancer related deaths. Despite modest success with therapy such as …

Nuclear factor-kappa B (NF-κB) is a transcription factor that plays a critical role across many
cellular processes including embryonic and neuronal development, cell proliferation …