Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …

Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor
tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical …

Head and neck tumors belong among the six leading causes of cancer death worldwide.
The predominant type of head and neck tumors consists of squamous cell carcinomas …

Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of
cancer and the first step towards metastasis. Penetrating to adjacent tissues, tumor cells …

Background: Protrusive structures formed by migrating and invading cells are termed
lamellipodia, filopodia, invadopodia and podosomes. Lamellipodia and filopodia appear on …

Abstract Treatment planning for oral squamous cell carcinoma (OSCC) is based on the
clinical TNM (Tumor, Node and Metastasis) classification. This system operates on the …

We have previously identified 1 241 regions of somatic copy number alterations (CNAs) in
hepatocellular carcinoma (HCC). In the present study, we found that a novel recurrent focal …

During glycolysis, the muscle isoform of pyruvate kinase PKM2 produces ATP in exchange
for dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate. PKM2 has been …