Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

[HTML][HTML] Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

[HTML][HTML] Intranasal oxytocin in children and adolescents with autism spectrum disorder

L Sikich, A Kolevzon, BH King… - … England Journal of …, 2021 - Mass Medical Soc
Background Experimental studies and small clinical trials have suggested that treatment
with intranasal oxytocin may reduce social impairment in persons with autism spectrum …

[HTML][HTML] Advances in human oxytocin measurement: challenges and proposed solutions

BA Tabak, G Leng, A Szeto, KJ Parker… - Molecular …, 2023 - nature.com
Oxytocin, a neuropeptide known for its role in reproduction and socioemotional processes,
may hold promise as a therapeutic agent in treating social impairments in patient …

[HTML][HTML] Brain oxytocin: how puzzle stones from animal studies translate into psychiatry

V Grinevich, ID Neumann - Molecular psychiatry, 2021 - nature.com
The neuropeptide oxytocin has attracted great attention of the general public, basic
neuroscience researchers, psychologists, and psychiatrists due to its profound pro-social …

[HTML][HTML] The impact of atypical sensory processing on social impairments in autism spectrum disorder

MD Thye, HM Bednarz, AJ Herringshaw… - Developmental cognitive …, 2018 - Elsevier
Altered sensory processing has been an important feature of the clinical descriptions of
autism spectrum disorder (ASD). There is evidence that sensory dysregulation arises early …

Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism

KJ Parker, O Oztan, RA Libove… - Proceedings of the …, 2017 - National Acad Sciences
Autism spectrum disorder (ASD) is characterized by core social deficits. Prognosis is poor, in
part, because existing medications target only associated ASD features. Emerging evidence …

Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

ID Neumann, R Landgraf - Trends in neurosciences, 2012 - cell.com
Oxytocin and vasopressin are regulators of anxiety, stress-coping, and sociality. They are
released within hypothalamic and limbic areas from dendrites, axons, and perikarya …

Oxytocin pathway genes: evolutionary ancient system impacting on human affiliation, sociality, and psychopathology

R Feldman, M Monakhov, M Pratt, RP Ebstein - Biological psychiatry, 2016 - Elsevier
Oxytocin (OT), a nonapeptide signaling molecule originating from an ancestral peptide,
appears in different variants across all vertebrate and several invertebrate species …

[HTML][HTML] Rethinking schizophrenia

TR Insel - Nature, 2010 - nature.com
How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …