The thalamus is a crucial node for brain physiology and part of functional and structural
pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have …

Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of
therapeutic intervention for schizophrenia. However, about one third of people do not …

Mutations of DISC1 (disrupted-in-schizophrenia 1) have been associated with major
psychiatric disorders. Despite the hundreds of DISC1-binding proteins reported, almost …

Short-term memory dysfunction is a key early feature of Alzheimer's disease (AD).
Psychiatric patients may be at higher risk for memory dysfunction and subsequent AD due to …

Women are under-represented in research on suicidality to date. Although women have a
lower rate of suicide completion than men, due in part to the less-violent methods used, they …

Genetic risk for schizophrenia (SCZ) is determined by many genetic loci whose compound
biological effects are difficult to determine. We hypothesized that co-expression pathways of …

Abstract Glycogen synthase kinase-3 (GSK-3) is a highly conserved and multifunctional
serine/threonine protein kinase widely distributed in eukaryotic cells. GSK-3 is originally …

Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical
physiology and response to treatment with antipsychotics in schizophrenia. Similarly …

Decades of research have established a model that includes the medial temporal lobe, and
particularly the hippocampus, as a critical node for episodic memory. Neuroimaging and …

Although the dopamine D2 receptor (DRD2) has been a main target of antipsychotic
pharmacotherapy for the treatment of schizophrenia, the standard treatment does not offer …