What is the pipeline for future medications for obesity?

E Melson, U Ashraf, D Papamargaritis… - International Journal of …, 2024 - nature.com
Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …

Modern management of cardiometabolic continuum: from overweight/obesity to prediabetes/type 2 diabetes mellitus. Recommendations from the Eastern and …

A Janez, E Muzurovic, P Bogdanski, L Czupryniak… - Diabetes Therapy, 2024 - Springer
The increasing global incidence of obesity and type 2 diabetes mellitus (T2D) underscores
the urgency of addressing these interconnected health challenges. Obesity enhances …

Impact of the metabolic syndrome on cardiopulmonary morbidity and mortality in individuals with lung function impairment: a prospective cohort study of the Danish …

JL Marott, TS Ingebrigtsen, Y Çolak… - The Lancet Regional …, 2023 - thelancet.com
Background Whether the metabolic syndrome plays a role for the prognosis of individuals
with lung function impairment (preserved ratio impaired spirometry (PRISm) or airflow …

[HTML][HTML] Future therapies for obesity

E Melson, AD Miras, D Papamargaritis - Clinical Medicine, 2023 - Elsevier
Obesity is a chronic disease associated with increased morbidity and mortality. Bariatric
surgery can lead to sustained long-term weight loss (WL) and improvement in multiple …

From metabolic syndrome to type 2 diabetes in youth

D Iafusco, R Franceschi, A Maguolo, S Guercio Nuzio… - Children, 2023 - mdpi.com
In the frame of metabolic syndrome, type 2 diabetes emerges along a continuum of the risk
from the clustering of all its components, namely visceral obesity, high blood pressure and …

[HTML][HTML] Time Restricted Eating: A Novel Dietary Strategy for Cardiac Rehabilitation

S Small, J Iglesies-Grau, C Gariepy, M Wilkinson… - Canadian Journal of …, 2023 - Elsevier
Cardiac rehabilitation (CR) is a multi-modal program considered standard of care for
secondary prevention of cardiovascular disease (CVD). The primary goals of CR are …

[HTML][HTML] Efficacy and safety of tirzepatide in type 2 diabetes and obesity management

R Sinha, D Papamargaritis, JA Sargeant… - Journal of obesity & …, 2023 - ncbi.nlm.nih.gov
The combination of glucagon-like peptide-1 (GLP-1) with other gut hormones including the
glucose-dependent insulinotropic polypeptide (GIP) has been explored to complement and …

Efficacy of intragastric balloon versus liraglutide as bridge to surgery in super-obese patients

G Martines, A Dezi, C Giove, V Lantone, MT Rotelli… - Obesity Facts, 2023 - karger.com
Introduction: Bariatric surgery is a safe and effective treatment for obesity, although in super-
obese patients (BMI≥ 50 kg/m 2) it can become challenging for anatomical and …

[HTML][HTML] Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?

E Domingo, P Marques, V Francisco, L Piqueras… - Pharmacological …, 2024 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death and disability worldwide.
While many factors can contribute to CVD, atherosclerosis is the cardinal underlying …

The Obese Brain

S Carmo-Silva, C Nóbrega - Obesity: Clinical, Surgical and Practical Guide, 2024 - Springer
This chapter explores the complex relationship between the brain and body weight
regulation, focusing on the disruptive impact of obesity. The brain, specifically the …