Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Recent advances of using exosomes as diagnostic markers and targeting carriers for cardiovascular disease

N Li, T Zhang, L Zhu, L Sun, G Shao… - Molecular …, 2023 - ACS Publications
Cardiovascular diseases (CVDs) are the leading cause of human death worldwide.
Exosomes act as endogenous biological vectors; they possess advantages of low …

C1q/TNF-related protein 9 attenuates atherosclerosis by inhibiting hyperglycemia-induced endothelial cell senescence through the AMPKα/KLF4 signaling pathway

G Wang, B Han, R Zhang, Q Liu, X Wang… - Frontiers in …, 2021 - frontiersin.org
Hyperglycemia-induced endothelial cell senescence has been widely reported to be
involved in the pathogenesis of type 2 diabetes mellitus‒accelerated atherosclerosis. Thus …

Mesenchymal stromal cell-derived extracellular vesicles for vasculopathies and angiogenesis: therapeutic applications and optimization

Y Zhu, ZF Liao, MH Mo, XD Xiong - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs), as part of the cellular secretome, have emerged as essential
cell–cell communication regulators in multiple physiological and pathological processes …

VEGFA‐enriched exosomes from tendon‐derived stem cells facilitate tenocyte differentiation, migration, and transition to a fibroblastic phenotype

Z Xue, Z Chen, T Wu, R Li, C Chen, J Liu… - BioMed Research …, 2022 - Wiley Online Library
Tendon‐derived stem cells (TDSCs) play a vital role in repair of rotator cuff tear injuries by
secreting paracrine proteins that regulate resident cell functions. Secreted exosomes may …

Stem cell-based therapy in cardiac repair after myocardial infarction: Promise, challenges, and future directions

W Yan, Y Xia, H Zhao, X Xu, X Ma, L Tao - Journal of Molecular and …, 2024 - Elsevier
Stem cells represent an attractive resource for cardiac regeneration. However, the survival
and function of transplanted stem cells is poor and remains a major challenge for the …

Extracellular vesicles from NMN preconditioned mesenchymal stem cells ameliorated myocardial infarction via miR-210-3p promoted angiogenesis

Y Pu, C Li, X Qi, R Xu, L Dong, Y Jiang, Q Gong… - Stem Cell Reviews and …, 2023 - Springer
Mesenchymal stem cell-derived extracellular vesicles (MSCs-EVs) possess cardioprotection
in acute myocardial infarction. Nevertheless, the therapeutic intervention potential and the …

[HTML][HTML] Advances in the Study of Exosomes in cardiovascular diseases

Z Zhang, Y Zou, C Song, K Cao, K Cai, Y Wu… - Journal of Advanced …, 2023 - Elsevier
Background Cardiovascular disease (CVD) has been the leading cause of death worldwide
for many years. In recent years, exosomes have gained extensive attention in the …

Current optimized strategies for stem cell-derived extracellular vesicle/exosomes in cardiac repair

R Wu, X Hu, J Wang - Journal of Molecular and Cellular Cardiology, 2023 - Elsevier
Ischemic heart diseases remain the leading cause of death globally, and stem cell-based
therapy has been investigated as a potential approach for cardiac repair. Due to poor …

From beats to metabolism: the heart at the core of interorgan metabolic cross talk

R Romero-Becera, AM Santamans, AC Arcones… - …, 2024 - journals.physiology.org
The heart, once considered a mere blood pump, is now recognized as a multifunctional
metabolic and endocrine organ. Its function is tightly regulated by various metabolic …