Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic
small‐molecule ligands. Ligand‐binding specificities can be strict or promiscuous. Serum …

There have been many attempts to identify common biophysical properties which
differentiate allergens from their non-immunogenic counterparts. This review will focus on …

Aeroallergens or inhalant allergens, are proteins dispersed through the air and have the
potential to induce allergic conditions such as rhinitis, conjunctivitis, and asthma. Outdoor …

Vicilin-buried peptides (VBPs) from edible plants are derived from the N-terminal leader
sequences (LSs) of seed storage proteins. VBPs are defined by a common α-hairpin fold …

The continuous search for new allergens and the design of allergen derivatives improves
the understanding of their allergenicity and aids the design of novel diagnostic and …

Many major allergens bind to hydrophobic lipid-like molecules, including Mus m 1, Bet v 1,
Der p 2, and Fel d 1. These ligands are strongly retained and have the potential to influence …

Only a small fraction of environmental proteins encountered by the human immune system
consistently induce allergic sensitization. This suggests that the presence of specific …

The direct link between a protein's thermodynamic stability and function influenced the
development of mass spectrometry-based methods to characterize the energetics …