The management of retinoblastoma, the most common intraocular malignancy in children,
has changed drastically over the last decade. Landmark developments in local drug …

Cancer immunotherapy has emerged as a novel anti-tumor treatment. Despite significant
breakthroughs, cancer immunotherapy remains focused on several types of tumors that are …

Background Recurrence of retinoblastoma (RB) following chemoreduction is common and is
often managed with local (intra-arterial/intravitreal) chemotherapy. However, some tumors …

Most retinoblastomas develop from maturing cone precursors in response to biallelic RB1
loss and are dependent on cone maturation-related signaling. Additionally,∼ 2% lack RB1 …

Retinoblastoma is the most common paediatric neoplasm of the retina, and one of the
earliest model of cancer genetics since the identification of the master tumour suppressor …

Background MYCN-amplified RB1 wild-type (MYCN A RB1+/+) retinoblastoma is a rare but
clinically important subtype of retinoblastoma due to its aggressive character and relative …

Background This study determined to probe the potential association between somatic copy
number alteration (SCNA) in retinoblastoma (RB) aqueous humour (AH) and pathological …

Purpose Retinoblastoma, a childhood cancer, is most frequently caused by bi-allelic
inactivation of RB1 gene. However, other oncogenic mutations such as MYCN amplification …

Simple Summary Retinoblastoma (RB) is a cancer in children, caused by loss of function of
RB1 gene. Additional factors such as increase in gene copy numbers of oncogenes MYCN …

Purpose: Although there have been improvements in the management of metastatic
retinoblastoma, most patients do not survive, and all patients suffer from multiple short-and …