Evolutionary rescue in a fluctuating environment: periodic versus quasi-periodic environmental changes

L Marrec, C Bank - Proceedings of the Royal Society B, 2023 - royalsocietypublishing.org
No environment is constant over time, and environmental fluctuations impact the outcome of
evolutionary dynamics. Survival of a population not adapted to some environmental …

High level of medication adherence is required to lower mortality in patients with chronic hepatitis B taking entecavir: A nationwide cohort study

J Lee, S Cho, HJ Kim, H Lee, MJ Ko… - Journal of Viral …, 2021 - Wiley Online Library
It is unclear whether suboptimal adherence contributes to adverse clinical outcomes in
patients with chronic hepatitis B (CHB). Moreover, there is no consensus regarding the …

Association between medication adherence and disease outcomes in patients with hepatitis B-related cirrhosis: a population-based case–control study

KY Fu, ML Hsieh, JA Chen, VCR Hsieh - BMJ open, 2022 - bmjopen.bmj.com
Objective To evaluate medication adherence among patients with hepatitis B-related
cirrhosis who developed decompensation and mortality, and to examine the association …

The risk of drug resistance during long-acting antimicrobial therapy

A Nande, AL Hill - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
The emergence of drug resistance during antimicrobial therapy is a major global health
problem, especially for chronic infections like human immunodeficiency virus, hepatitis B …

Classification of virologic trajectories during nucleos/tide analogue treatment of hepatitis B virus (HBV) infection

T Wang, C Campbell, AJ Stockdale, S Todd, K McIntyre… - medRxiv, 2023 - medrxiv.org
Background & Aims: The dynamics of HBV viral load (VL) in patients with chronic hepatitis B
(CHB) on nucleos/tide analogue (NA) treatment and its relationship with liver disease are …

Epidemiological trends and outcomes of primary biliary cholangitis in South Korea between 2009 and 2019

KA Kim, HY Choi, M Ki, ES Jang, SH Jeong - Journal of Gastroenterology, 2023 - Springer
Background There are no longitudinal studies on the epidemiology of primary biliary
cholangitis (PBC) in Korea. This study aimed to elucidate the temporal trends in the …

Factors Associated With Adherence to First-line Antiviral Therapy Among Commercially Insured Patients With Chronic Hepatitis B

JD Alpern, H Joo, NC Bahr… - Open Forum Infectious …, 2023 - academic.oup.com
Background Nonadherence to antiviral therapy can lead to poor clinical outcomes among
patients with chronic hepatitis B (CHB). We used a claims database to evaluate risk factors …

Evolutionary rescue in a fluctuating environment

L Marrec, C Bank - bioRxiv, 2022 - biorxiv.org
No environment is constant over time, and environmental fluctuations impact the outcome of
evolutionary dynamics. Survival of a population not adapted to some environmental …

Real world clinical experience of Chronic Hepatitis B Treatment in SSA

A Bane, A Sultan, Z Tibebu, R Ahmed - 2023 - researchsquare.com
Background About three hundred fifty to four hundred million people are infected chronically
with hepatitis B worldwide and about 780,000 people die annually of its complications …

[PDF][PDF] MAJOR ARTICLE

JD Alpern, H Joo, NC Bahr, TM Leventhal - researchgate.net
Background: Non-adherence to anti-viral therapy can lead to poor clinical outcomes among
patients with chronic hepatitis B (CHB). We used a claims database to evaluate risk factors …