Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …

The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …

Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome.
Although the translation of circRNAs was reported, additional coding circRNAs and the …

Elucidation of the mutational landscape of human cancer has progressed rapidly and been
accompanied by the development of therapeutics targeting mutant oncogenes. However, a …

Recent studies have highlighted that splicing patterns are frequently altered in cancer and
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …

Mutations affecting spliceosomal proteins are the most common mutations in patients with
myelodysplastic syndromes (MDS), but their role in MDS pathogenesis has not been …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

MYC (also known as c-MYC) overexpression or hyperactivation is one of the most common
drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to …