[HTML][HTML] Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

[HTML][HTML] Recent advances in targeted strategies for triple-negative breast cancer

S Zhu, Y Wu, B Song, M Yi, Y Yan, Q Mei… - Journal of Hematology & …, 2023 - Springer
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer,
negatively expresses estrogen receptor, progesterone receptor, and the human epidermal …

[HTML][HTML] The role of organoids in cancer research

Z Fang, P Li, F Du, L Shang, L Li - Experimental Hematology & Oncology, 2023 - Springer
Organoids are established through in vitro 3D culture, and they can mimic the structure and
physiological functions of organs or tissues in vivo. Organoids have attracted much attention …

[HTML][HTML] Predictive biomarkers of response to neoadjuvant chemotherapy in breast cancer: current and future perspectives for precision medicine

F Derouane, C van Marcke, M Berlière, A Gerday… - Cancers, 2022 - mdpi.com
Simple Summary Despite the increased use of neoadjuvant chemotherapy in the early
setting of breast cancer, there is a clinical need for predictive markers of response in daily …

[HTML][HTML] Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology

L Thorel, M Perréard, R Florent, J Divoux… - … & Molecular Medicine, 2024 - nature.com
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has
broadened the repertoire of preclinical models and progressively revolutionized three …

From digital control to digital twins in medicine: A brief review and future perspectives

R Eftimie, A Mavrodin, SPA Bordas - Advances in Applied Mechanics, 2023 - Elsevier
The last few decades have been dominated by the need for digital control of various
processes in biology and medicine. Advances in artificial intelligence (AI) over the last few …

Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment

K Ravi, TJM Manoharan, KC Wang, B Pockaj… - Biomaterials, 2023 - Elsevier
Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …

[HTML][HTML] Head and neck cancer patient-derived tumouroid cultures: Opportunities and challenges

BWMTJ Basnayake, P Leo, S Rao, S Vasani… - British Journal of …, 2023 - nature.com
Head and neck cancers (HNC) are the seventh most prevalent cancer type globally. Despite
their common categorisation, HNCs are a heterogeneous group of malignancies arising in …

Microfluidic organoid cultures derived from pancreatic cancer biopsies for personalized testing of chemotherapy and immunotherapy

D Choi, AM Gonzalez‐Suarez, MG Dumbrava… - Advanced …, 2024 - Wiley Online Library
Patient‐derived cancer organoids (PDOs) hold considerable promise for personalizing
therapy selection and improving patient outcomes. However, it is challenging to generate …

Mechanics constitutive models for viscoelastic solid materials: Development and a critical review

X Zhou, D Yu, O Barrera - Advances in Applied Mechanics, 2023 - Elsevier
Mathematical constitutive models are crucially important for the real viscoelastic solid
materials in academic investigation and engineering application. The viscoelastic solid …