Molecular docking has been widely employed as a fast and inexpensive technique in the
past decades, both in academic and industrial settings. Although this discipline has now had …

Zika virus is an emerging flavivirus that causes the neurodevelopmental congenital Zika
syndrome and that has been linked to the neuroinflammatory Guillain–Barré syndrome. The …

Fragment-based drug discovery is a strategy widely used in both academia and
pharmaceutical companies to generate small-molecule protein inhibitors and drug …

RNA methyltransferases (MTases) are ubiquitous enzymes whose hitherto low profile in
medicinal chemistry, contrasts with the surging interest in RNA methylation, the arguably …

Culex mosquitoes are the primary vectors of the Japanese encephalitis virus (JEV). Since its
discovery in 1935, Japanese encephalitis (JE), caused by JEV, has posed a significant …

Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika
virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral …

Emerging and/or re-emerging viral diseases such as dengue and Zika are a worldwide
concern. Therefore, new antiviral therapeutics are necessary. In this sense, a non-structural …

In drug discovery, the successful optimization of an initial hit compound into a lead molecule
requires multiple cycles of chemical modification. Consequently, there is a need to efficiently …

Infection by Zika virus (ZIKV), a mosquito-transmitted arbovirus and a member of Flavivirus,
could make pediatric microcephaly and Guillain–Barré syndrome, which remains an …

Flaviviruses are among the most critical pathogens in tropical regions and cause a growing
number of severe diseases in developing countries. The development of antiviral …