The cellular response to radiation and various chemotherapy drugs, whose mechanism in
part includes production of free radicals or DNA damage, may be altered by modification of …

The currently available flow cytometric stains for cellular glutathione were evaluated,
examining the labelling of both human and rodent cell lines under various conditions of …

PURPOSE A phase I dose-escalation trial of intravenous (IV) L-buthionine-SR-sulfoximine
(BSO) with melphalan (L-PAM) was performed to determine the toxicity and biologic activity …

Radiosensitizers and radioprotectors are part of the chemical modifier approach to cancer
therapy whereby the state of the tumor cells and/or normal tissues are modified such that a …

We have studied the effect of glutathione reduction by buthionine sulf-oximine (BSO), a
specific inhibitor ofλ-glutamyl cysteine synthetase, on DNA repair after cisplatin damage in …

We have cloned and sequenced a full-length cDNA for human liver γ-glutamylcysteine
synthetase (GCS), the rate-limiting enzyme in glutathione biosynthesis. The cDNA consists …

Glutathione-dependent enzymes play a central role in the protection of cells from cytotoxic
chemicals and have been implicated in the intrinsic and acquired resistance of tumors to …

The univalent reduction of oxygen results in the production of superoxide radicals.
Superoxide radicals are generated in many biological reactions that can reduce molecular …

The two principal subtypes of glial neoplasms, astrocytomas and oligodendrogliomas,
exhibit striking differences in response to chemotherapy. This differential chemosensitivity …

Levels of intracellular glutathione (GSH) and the GSH-related enzymes γ-glutamylcysteine
synthetase (γ-GCS) and γ-glutamyltranspeptidase (γ-GT) were measured in the melphalan …