Neuroinflammation in psychiatric disorders: PET imaging and promising new targets
Neuroinflammation is a multifaceted physiological and pathophysiological response of the
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
brain to injury and disease. Given imaging findings of 18 kDa translocator protein (TSPO) …
[HTML][HTML] Recent developments in TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders
Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …
involve the activation of microglia and astrocytes. It is a common feature of many central …
[HTML][HTML] Elusive roles for reactive astrocytes in neurodegenerative diseases
L Ben Haim, MA Carrillo-de Sauvage… - Frontiers in cellular …, 2015 - frontiersin.org
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory
response. They become reactive in response to virtually all pathological situations in the …
response. They become reactive in response to virtually all pathological situations in the …
Neuroinflammation in neurodegenerative disorders—a review
M Schain, WC Kreisl - Current neurology and neuroscience reports, 2017 - Springer
The potential for positron emission tomography (PET) to detect neuroinflammation in vivo
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …
Roles of microglia in brain development, tissue maintenance and repair
The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …
brain with a growing interest in their diverse functions. In recent years, it has been …
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28
[11C] PBR28 binds the 18-kDa Translocator Protein (TSPO) and is used in positron
emission tomography (PET) to detect microglial activation. However, quantitative …
emission tomography (PET) to detect microglial activation. However, quantitative …
[HTML][HTML] Targeting neuroinflammation to treat Alzheimer's disease
A Ardura-Fabregat, E Boddeke, A Boza-Serrano… - CNS drugs, 2017 - Springer
Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
pathomechanisms linked to two of the major pathological hallmarks of extracellular …
Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …
[HTML][HTML] Neuroinflammation after intracerebral hemorrhage
E Mracsko, R Veltkamp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …
no specific treatment has been established yet. Although preclinical models of ICH have …